abstract：:The long held assumption that sustained drug elution from stent coatings over weeks to months is imperative for clinical efficacy has limited the choice for stent coating materials. We developed and evaluated an omega-3 fatty acid (O3FA) based stent coating that is 85% absorbed and elutes 97% of its Sirolimus analog (...

journal_title：Annals of biomedical engineering

authors： Artzi N,Tzafriri AR,Faucher KM,Moodie G,Albergo T,Conroy S,Corbeil S,Martakos P,Virmani R,Edelman ER

更新日期：2016-02-01 00:00:00

abstract：:In recent years, advances in computing power and computational methods have made it possible to perform detailed simulations of the coronary artery stenting procedure and of related virtual tests of performance (including fatigue resistance, corrosion and haemodynamic disturbance). Simultaneously, there has been a gro...

journal_title：Annals of biomedical engineering

authors： Bressloff NW,Ragkousis G,Curzen N

更新日期：2016-02-01 00:00:00

abstract：:The field of percutaneous coronary intervention has witnessed many progressions over the last few decades, more recently with the advancement of fully degradable bioabsorbable stents. Bioabsorbable materials, such as metallic alloys and aliphatic polyesters, have the potential to yield stents which provide temporary s...

journal_title：Annals of biomedical engineering

authors： Boland EL,Shine R,Kelly N,Sweeney CA,McHugh PE

更新日期：2016-02-01 00:00:00

abstract：:A cohesive zone model (CZM) approach is applied to simulate atherosclerotic plaque delamination experiments in mouse abdominal aorta specimens. A three-dimensional finite element model is developed for the experiments. The aortic wall is treated as a fiber-reinforced, highly deformable, incompressible material, and th...

journal_title：Annals of biomedical engineering

authors： Leng X,Chen X,Deng X,Sutton MA,Lessner SM

更新日期：2015-12-01 00:00:00

abstract：:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacia...

journal_title：Annals of biomedical engineering

authors： Kinneberg KR,Nelson A,Stender ME,Aziz AH,Mozdzen LC,Harley BA,Bryant SJ,Ferguson VL

更新日期：2015-11-01 00:00:00

abstract：:A novel electrocardiogram (ECG) electrode film is developed by mixing carbon black powder and a quaternary salt with a visco-elastic polymeric adhesive. Unlike traditional wet gel-based electrodes, carbon/salt/adhesive (CSA) electrodes should theoretically have an infinite shelf life as they do not dehydrate even afte...

journal_title：Annals of biomedical engineering

authors： Posada-Quintero HF,Reyes BA,Burnham K,Pennace J,Chon KH

更新日期：2015-10-01 00:00:00

abstract：:Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment of endothelial progenitor cells (EPCs). This mobilization and homing is a multi-step pr...

journal_title：Annals of biomedical engineering

authors： Williams PA,Silva EA

更新日期：2015-10-01 00:00:00

abstract：:Intraluminal thrombus (ILT) is a pseudo-tissue that develops from coagulated blood, and is found in most abdominal aortic aneurysms (AAAs) of clinically relevant size. A number of studies have suggested that ILT mechanical characteristics may be related to AAA risk of rupture, even though there is still great controve...

journal_title：Annals of biomedical engineering

authors： Riveros F,Martufi G,Gasser TC,Rodriguez-Matas JF

更新日期：2015-09-01 00:00:00

abstract：:Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...

journal_title：Annals of biomedical engineering

authors： Vavalle NA,Davis ML,Stitzel JD,Gayzik FS

更新日期：2015-09-01 00:00:00

abstract：:Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....

journal_title：Annals of biomedical engineering

authors： Bozkurt S,van de Vosse FN,Rutten MC

更新日期：2015-08-01 00:00:00

abstract：:Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or "stenting" is not free of complications. Stent malapposition (SM) is a common feature of "stenting" particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an i...

journal_title：Annals of biomedical engineering

authors： Ragkousis GE,Curzen N,Bressloff NW

更新日期：2015-08-01 00:00:00

abstract：:Mechanical interactions during angiogenesis, i.e., traction applied by neovessels to the extracellular matrix and the corresponding deformation, are important regulators of growth and neovascularization. We have previously designed, implemented, and validated a coupled model of angiogenesis in which a discrete microve...

journal_title：Annals of biomedical engineering

authors： Edgar LT,Hoying JB,Weiss JA

更新日期：2015-07-01 00:00:00

abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...

journal_title：Annals of biomedical engineering

authors： Iasiello M,Vafai K,Andreozzi A,Bianco N,Tavakkoli F

更新日期：2015-07-01 00:00:00

abstract：:Understanding the characteristic morphology of our brain remains a challenging, yet important task in human evolution, developmental biology, and neurosciences. Mathematical modeling shapes our understanding of cortical folding and provides functional relations between cortical wavelength, thickness, and stiffness. Ye...

journal_title：Annals of biomedical engineering

authors： Holland MA,Miller KE,Kuhl E

更新日期：2015-07-01 00:00:00

abstract：:The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid mode...

journal_title：Annals of biomedical engineering

authors： Aristokleous N,Seimenis I,Georgiou GC,Nicolaides A,Anayiotos AS

更新日期：2015-06-01 00:00:00

abstract：:Newborns with single ventricle physiology are usually palliated with a multi-staged procedure. When cardiovascular complications e.g., collateral vessel formation occur during the inter-stage periods, further treatments are required. An 8-month-old patient, who underwent second stage (i.e., bi-directional Glenn, BDG) ...

journal_title：Annals of biomedical engineering

authors： Corsini C,Baker C,Baretta A,Biglino G,Hlavacek AM,Hsia TY,Kung E,Marsden A,Migliavacca F,Vignon-Clementel I,Pennati G,Modeling of Congenital Hearts Alliance (MOCHA) Investigators.

更新日期：2015-06-01 00:00:00

abstract：:In this study, cell-material adhesive strength and cellular mechanical properties were measured using atomic force microscopy (AFM) to track cell attachment and osteogenic differentiation. First, chitosan substrates were treated with simulated body fluid (SBF) for various periods, resulting in substrates with differen...

journal_title：Annals of biomedical engineering

authors： Ho MH,Li CH,Hsiao SW,Thien DV

更新日期：2015-04-01 00:00:00

abstract：:Tissue engineering strategies have utilized a wide spectrum of synthetic and naturally-derived scaffold materials. Synthetic scaffolds are better defined and offer the ability to precisely and reproducibly control their properties, while naturally-derived scaffolds typically have inherent biological and structural pro...

journal_title：Annals of biomedical engineering

authors： Allen AB,Priddy LB,Li MT,Guldberg RE

更新日期：2015-03-01 00:00:00

abstract：:Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recru...

journal_title：Annals of biomedical engineering

authors： Glowacki AJ,Gottardi R,Yoshizawa S,Cavalla F,Garlet GP,Sfeir C,Little SR

更新日期：2015-03-01 00:00:00

abstract：:Much effort is expended in developing biomimetic scaffolds that provide the micro-architecture of native tissue with appropriate cellular niches. Such scaffolds are often seeded with progenitor cells to generate engineered replacements for diseased or damaged tissues. An alternative approach relies on biology, rather ...

journal_title：Annals of biomedical engineering

authors： Evans CH

更新日期：2015-03-01 00:00:00

abstract：:Skeletal muscles can be injured by their own contractions. Such contraction-induced injury, often accompanied by delayed onset of muscle soreness, is a leading cause of the loss of mobility in the rapidly increasing population of elderly people. Unlike other types of muscle injuries which hurt almost exclusively those...

journal_title：Annals of biomedical engineering

authors： Givli S

更新日期：2015-02-01 00:00:00

abstract：:For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...

journal_title：Annals of biomedical engineering

authors： van Meulen FB,Reenalda J,Buurke JH,Veltink PH

更新日期：2015-02-01 00:00:00

abstract：:Pressure ulcers (PUs) can occur in any situations where people are subjected to non-uniform distribution of pressure over a prolonged period. They can have devastating effects on the patients' well-being and in extreme conditions can prove fatal. In addition to traditional wisdom implicating mechanically induced ischa...

journal_title：Annals of biomedical engineering

authors： Mirtaheri P,Gjøvaag T,Worsley PR,Bader DL

更新日期：2015-02-01 00:00:00

abstract：:Bending stiffness of passive-dynamic ankle-foot orthoses (PD-AFOs) is a functional characteristic thought to restore lost ankle function due to weakened plantar flexors. However, lower extremity impairment profiles of patients are seldom limited to plantar flexion weakness, and PD-AFO characteristics often influence g...

journal_title：Annals of biomedical engineering

authors： Arch ES,Stanhope SJ

更新日期：2015-02-01 00:00:00

abstract：:Clinicians generally assume that Medical Compression Stockings (MCS) work by reducing vein luminal diameter and, in this way, help to prevent blood pooling. Conflicting results have been reported however in the case of lower leg deep veins which call into question this hypothesis. The purpose of this contribution is t...

journal_title：Annals of biomedical engineering

authors： Rohan PY,Badel P,Lun B,Rastel D,Avril S

更新日期：2015-02-01 00:00:00

abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...

journal_title：Annals of biomedical engineering

authors： Kafri M,Laufer Y

更新日期：2015-02-01 00:00:00

abstract：:Uncomplicated acute type B aortic dissections are usually treated medically, but they can become acutely complicated by rapid expansion, rupture and malperfusion syndromes and in the longer term by chronic dilatation and aortic aneurysm formation. The objective of this study is to use computational fluid dynamics reco...

journal_title：Annals of biomedical engineering

authors： Cheng Z,Wood NB,Gibbs RG,Xu XY

更新日期：2015-01-01 00:00:00

abstract：:Rupture of abdominal aortic aneurysm (AAA) is associated with high mortality rates. Risk of rupture is multi-factorial involving AAA geometric configuration, vessel tortuosity, and the presence of intraluminal pathology. Fluid structure interaction (FSI) simulations were conducted in patient based computed tomography ...

journal_title：Annals of biomedical engineering

authors： Xenos M,Labropoulos N,Rambhia S,Alemu Y,Einav S,Tassiopoulos A,Sakalihasan N,Bluestein D

更新日期：2015-01-01 00:00:00

abstract：:This paper presents the permeability analysis of neuroactive drugs and correlation with in vivo brain/plasma ratios in a dynamic microfluidic blood-brain barrier (BBB) model. Permeability of seven neuroactive drugs (Ethosuximide, Gabapentin, Sertraline, Sunitinib, Traxoprodil, Varenicline, PF-304014) and trans-endothe...

journal_title：Annals of biomedical engineering

authors： Booth R,Kim H

更新日期：2014-12-01 00:00:00

abstract：:A method of investigating head acceleration and intracranial dynamics from stick impacts in girls' and women's lacrosse was developed using headform impact experiments and a finite element head model. Assessing the likelihood of head injury due to stick-head impacts is of interest in girls' and women's lacrosse due to...

journal_title：Annals of biomedical engineering

authors： Morse JD,Franck JA,Wilcox BJ,Crisco JJ,Franck C

更新日期：2014-12-01 00:00:00

abstract：:This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...

journal_title：Annals of biomedical engineering

authors： Hu Y,Kim EG,Cao G,Liu S,Xu Y

更新日期：2014-11-01 00:00:00

abstract：:A major benefit of computational modeling in biomechanics research is its ability to estimate internal muscular demands given limited input information. However, several assumptions regarding model parameters and constraints may influence model outputs. This research evaluated the influence of model parameter variabil...

journal_title：Annals of biomedical engineering

authors： Chopp-Hurley JN,Langenderfer JE,Dickerson CR

更新日期：2014-09-01 00:00:00

abstract：:This paper outlines a comprehensive parametric approach for quantifying mechanical properties of spatially heterogeneous thin biological specimens such as human breast tissue using contact-mode Atomic Force Microscopy. Using inverse finite element (FE) analysis of spherical nanoindentation, the force response from hyp...

journal_title：Annals of biomedical engineering

authors： Roy R,Desai JP

更新日期：2014-09-01 00:00:00

abstract：:To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose ...

journal_title：Annals of biomedical engineering

authors： Twal WO,Klatt SC,Harikrishnan K,Gerges E,Cooley MA,Trusk TC,Zhou B,Gabr MG,Shazly T,Lessner SM,Markwald RR,Argraves WS

更新日期：2014-07-01 00:00:00

abstract：:The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...

journal_title：Annals of biomedical engineering

authors： Bersi MR,Ferruzzi J,Eberth JF,Gleason RL Jr,Humphrey JD

更新日期：2014-06-01 00:00:00

abstract：:Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...

journal_title：Annals of biomedical engineering

authors： Man AJ,Leach JK,Bannerman P

更新日期：2014-06-01 00:00:00

abstract：:Patients with aortic stenosis present with calcium deposits on the native aortic valve, which can result in non-concentric expansion of Transcatheter Aortic Valve Replacement (TAVR) stents. The objective of this study is to evaluate whether eccentric deployment of TAVRs lead to turbulent blood flow and blood cell dama...

journal_title：Annals of biomedical engineering

authors： Gunning PS,Saikrishnan N,McNamara LM,Yoganathan AP

更新日期：2014-06-01 00:00:00

abstract：:In this paper, a novel cell stretcher design that mimics the real-time stretch of the heart wall is introduced. By culturing cells under stretched conditions that mimics the mechanical aspects of the native cardiac environment, better understanding on the role of biomechanical signaling on cell development can be achi...

journal_title：Annals of biomedical engineering

authors： Lau JJ,Wang RM,Black LD 3rd

更新日期：2014-05-01 00:00:00

abstract：:Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk f...

journal_title：Annals of biomedical engineering

authors： Zermatten E,Vetsch JR,Ruffoni D,Hofmann S,Müller R,Steinfeld A

更新日期：2014-05-01 00:00:00

abstract：:The pia-arachnoid complex (PAC) covering the brain plays an important role in the mechanical response of the brain during impact or inertial loading. Recent studies have revealed the complicated material behavior of the PAC. In this study, the nonlinear viscoelastic, transversely isotropic material properties of the P...

journal_title：Annals of biomedical engineering

authors： Jin X,Mao H,Yang KH,King AI

更新日期：2014-04-01 00:00:00